丁菲 助理研究员联系电话:027-84223798转101 |
教育背景
2011.9-2014.6 武汉大学化学与分子科学学院 博士
2009.9-2011.6 武汉大学化学与分子科学学院 硕士
2004.9-2008.6 武汉大学化学与分子科学学院 学士
工作经历
2014.7- 江汉大学交叉科学研究院 助理研究员
2008.7-2009.8 武汉百科药业有限公司 助理研究员
研究兴趣与方向
基于单糖的靶向抗肿瘤药物的合成与活性研究,建立针对特定的糖基转移酶和肿瘤相关糖蛋白的内源性适配体筛选技术平台。
主持和参与的项目
1.国家自然科学基金青年项目,适配子荧光探针和半乳糖基化壳聚糖协同靶向运输铂(IV)复合物对肝癌的原位诊断和治疗效果研究,项目编号:21602081,起止时间:2017/01-2019/12(主持人);
2.国家自然科学基金青年项目,新型天然α-葡萄糖苷酶抑制剂Penasulfate A及其衍生物的合成、活性研究,项目编号:21602082,起止时间:2017/01-2019/12(参与人);
已发表文章(SCI)
1. FeiDinga,b*, YangguangGaoa, XianranHea. Recent progresses in biomedical applications of aptamer-functionalized systems. Bioorganic&Medicinal Chemistry Letter. 2017, 27, 4256-4269.
2. FeiDinga,b*, YongminZhanga. Biomedical Applications of Glycoconjugates. Mini-Review in Medicinal Chemistry. 2016, Accepted Manuscript.
3. YangguangGao, Xianran He, Fei Ding and Yongmin Zhang. Recent progress in chemical syntheses of sphingosines and phytosphingosines. Synthesis. 2016,48, 4017–4037.
4. YangguangGao, Zhou Cao, Chengzhong Su, Zefeng Chen, Xianran He, Fei Ding, Hang Li, Yongmin Zhang. Chiron Approaches to the Antitumor Natural Product Fuzanin D. Synthesis. 2016,48,4471–4476;
5. YousongNie, Min Zhong, Zhiyuan Jiang, JianSun,YangguangGao, Fei Ding, Hang Li, Yongmin Zhang and Xianran He. Synthesis and potential anticonvulsant activity of new arylsulfonylsemicarbazide derivatives. Med. Chem. Res., 2016, 25, 1425–1432;
6. Fei Ding, ‡ [a] Shan Guo, ‡ [a] Min Xie, ‡ [a] Wei Luo[b], Chunhui Yuan[b], Weihua Huang[a], Yan Zhou[c], XiaoLian Zhang[b]* and Xiang Zhou[ab]*. Diagnositic applications of gastric carcinoma cell aptamers in vitro and in vivo. Talanta, 2015, 134, 30-36.
7. Fei Ding, Chunhui Yuan, Fan Wu, ShuangPeng, SufangTian, Xiao Lian Zhang and Xiang Zhou. Diagnosis applications of new hepatoma carcinoma cell aptamersn vitro. Anal. Methods, 2014, 6,8110.
8. Tingting Hong, Tianlu Wang, PuGuo, Xiwen Xing, Fei Ding, Yuqi Chen, Jingjun Wu, Jingwei Ma, Xiang Zhou*. “Fluorescent strategy for quantification of 5-hydroxymethylcytosine in genomic DNA based on CCP-FRET’’. Analytical chemistry, 2013, 85(22):1520-6882.
9. ShuoFeng, Ye Shang, Fan Wu, Fei Ding (co-first), Bin Li, JiahuiXu, Liang Xu, Xiang Zhou.DNA nanomachines as evolved molecular Beacons for in vitro andin vivo detection,Talanta,2013,120:141-147.
10. Fei Ding,Jun You,XiaochengWeng,Jinping Zhou,XiaolianZhang,Xiang Zhou,Lina Zhang,Exploring QuaternizedHydroxyethylcellulose as Potential Gene Carriers,Chin. J. Chem.,2012,30:2212-2218.
专利
1.丁菲,一种肝癌细胞特异性的适配子及其制备方法,中国,201510252948.0。
2.丁菲,周翔。特异性靶向胃癌细胞的适配子的筛选及筛选得到的适配子,中华人民共和国,201310645924.2。