贺贤然

教育背景
2011.2- 2013.2   University of Iowa，博士后(Postdoc)
2005.9-2010.12   武汉大学，药物化学专业，理学博士学位
2001.9-2005.6    湖北工业大学，制药工程专业，工学学士学位

工作经历
2013.2-至今    江汉大学交叉学科研究院   助理研究员

研究兴趣与方向
1、新型抗惊厥及抗癫痫药物[antiepileptic drugs (AEDs)]及前体药物的设计、合成与开发；
2、具有潜在生物活性的杂环化合物的合成方法及生物活性研究；
3、含糖功能化合物的合成及生物活性研究；
4、环境污染物代谢产物（PCBs，CPs）硫酸盐，及糖代谢产物研究及其标准品制备(与美国爱荷华大学公共卫生学院 Professor Hans joachim Lehmler合作)。

学术兼职
国际学术期刊“Eur. J. Med. Chem.”, “Medicinal Chemistry Research”,Neurological Research”审稿人，中国化学会会员，美国化学会（ACS）会员

科研项目：
国家自然科学基金青年基金（Grand No. 21302065）主持
国家自然科学基金青年基金（Grand No. 31100253）参与

已发表文章（SCI）
1.Xianran He, Min Zhong, Tao Zhang, Jin Yang, Zhongyuan Wu, Yuling Xiao, Hao Guo, Guofu Qiu, Xianming Hu. (2012) Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones. Eur J Med Chem. 48:338-346.
2.Xianran He, Min Zhong, Jin Yang, Zhongyuan Wu, Yuling Xiao, Hao Guo, Xianming Hu. (2012) Synthesis and anticonvulsant activity of 1-(2-(8-(benzyloxy)quinolin-2-yl)-1-butyrylcyclopropyl)-3-substituted urea derivatives. Chemical Biology & Drug Design. 79: 771-779.
3.Xianran He, Min Zhong, Tao Zhang, Wen Wu, Zhongyuan Wu, Yuling Xiao, Xianming Hu. (2012) Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives. Eur. J. Med. Chem.54: 542-548.
4.Xianran He,Guanpeng Qiu, Jin Yang, Yuling Xiao, Zhongyuan Wu, Guofu Qiu, Xianming Hu. (2010) Synthesis and anticonvulsant activity of new 6-methyl-1-substituted- 4,6-diazaspiro[2.4]heptane-5,7-diones.Eur J Med Chem; 45: 3818-3830.
5.Xianran He, Min Zhong, Tao Zhang, Wen Wu, Zhongyuan Wu, Jin Yang, Yu Ling Xiao, Yuanhu Pan, Guofu Qiu, Xianming Hu. (2010) Design, synthesis, and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. Eur. J. Med. Chem.45:5870-5877.
6.K Dhakal,  Xianran He, HJ Lehmler, LM Teesch, MW Duffel, LW Robertson. (2012) Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol. 25(12): 2796-2804.
7.HJ Lehmler, Xianran He, X Li, MW Duffel, S Parkin. (2013) Effective synthesis of sulfate metabolites of chlorinated phenols. Chemosphere.  On line Accepted
8.HJ Lehmler, Xianran He, MW Duffel, Parkin Sean. Acta crystal E. (2013) E69, o620.
9.Grimm FA, Lehmler HJ, Xianran He, Robertson LW, Duffel MW. (2013) Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin. Environ Health Perspect. 121(6): 657-662.
10.Jin Yang, Yuling Xiao, Xianran He, Zhongyuan Wu, Guofu Qiu, Xianming, Hu. (2010) Aesculetin-induced apoptosis through ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. J.Asian Nat. Prod. Res. 12 (3): 185 – 193.
11.Hao Guo, Guolan Zhang, Tao Zhang, Xianran He, Zhongyuan Wu, Yuling Xiao, Yuanhu Pan, Guofu Qiu, Peng Liu, Xianming Hu (2011) Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino- 5α-androstane derivatives as potential anticancer agents. Eur. J. Med. Chem .46:3662-3674. (IF 2010: 3.19)
12.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Hao Guo, Hao Hu, Dingshan Zhou, Xianming Hu, (2010) Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: A novel class of acylides. Eur. J. Med. Chem. 45:3636-3644.
13.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Yinya Xu, Wenhong Huang, Ping Long, Ruimin Li and Xianming Hu. (2010) Synthesis and antibacterial activity of novel 4″-carbamates of 6,11-di-O-methylerythromycin A. The Journal of Antibiotics: 63:343-350.
14.Yuling Xiao, Wenjin Xu, Qifeng Zhu, Bingfang Yan, Dongfang Yang, Jin Yang, Xianran He, Shucai Liang a, Xianming Hu, (2009) Preparation and characterization of a novel pachyman-based pharmaceutical aid.II: A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs. Carbohydrate Polymers., 77:612-620.
15.Jin Yang, Zhen Qu, Yuling Xiao, Guofu Qiu, Tao Zhang, Zhongyuan Wu, Xianran He, Xianming Hu.(2011) Chemical composition and antioxidant activity of the essential oil of endemic Viola tianshanica. Natural Product Research.25: 1635-1640.
16.Hao Guo, Haotian Wu, Jin Yang, Yuling Xiao, Hans Joachim Altenbach, Guofu Qiu, Hao Hu, Zhongyuan Wu, Xianran He, Dingshan Zhou, Xianming Hu (2011) Synthesis, characterization and biological evaluation of some 16E-arylidene and rostane derivatives as potential anticancer agents. Steroids. 76:709-723.
17.Yan Hu, Xianran He, Lei Lei, Shucai Liang, Guofu Qiu, Xianming Hu. (2008)Preparation and characterization of self-assembled nanoparticles of the novel carboxymethyl pachyman-deoxycholic acid conjugates. Carbohydrate Polymers, 74(2):220-227.