刘敏

教育背景
2004/09–2009/12   武汉大学   高分子化学与物理   博士
2000/09–2004/07   湖北大学   化学生物学             学士

工作经历
2018/07-至今，     江汉大学交叉学科研究院，副研究员
2015/01-2018/06，中国科学院苏州纳米技术与纳米仿生研究所，生物医学部，副研究员
2012/08-2014/12，中国科学院苏州纳米技术与纳米仿生研究所，生物医学部，助理研究员
2010/01-2012/07，中国科学院苏州纳米技术与纳米仿生研究所，博士后

主持项目
1.江汉大学高层次人才项目，40万，2018.07-2021.06。
2.江苏省重点研发计划，编号：BE2018665，用于脑胶质瘤早期诊断的跨血脑屏障和肿瘤靶向的纳米水凝胶钆基MRI造影剂研发及术中导航精准切除肿瘤研究，2018-2021，50万。
3.苏州市重点产业技术创新（前瞻性应用研究项目），用于生物器官再造的3D打印高性能成型材料的研发，2017-2019年，8万
4.江苏省面上项目，编号：BK20161262，基于适配体靶向的外泌体装载的钆基磁共振肿瘤高效造影剂构建及成像研究，2016-2019年，10万。
5.国家自然科学基金青年基金，编号：21304106，适配体靶向的纳米载体的钆基磁共振成像造影剂的构建研究，2014-2016年，25万。
6.苏州市科技项目应用基础研究计划基金，适配体靶向的聚赖氨酸树形分子修饰的壳聚糖纳米载体的钆基磁共振造影剂的设计与制备技术，2014-2016年，8万

已发表文章

通讯作者
1. Zhang, Y.; Chen, H.; Zhang, T.; Zan, Y.; Ni, T.; Cao, Y.; Wang, J.; Liu, M.*; Pei, R.*, Injectable hydrogels from enzyme-catalyzed crosslinking as BMSCs-laden scaffold for bone repair and regeneration. Materials Science and Engineering: C 2019, 96, 841-849.
2. Zhang, T.; Chen, H.; Zhang, Y.; Zan, Y.; Ni, T.; Liu, M.*;Pei, R.*, Photo-crosslinkable, bone marrow-derived mesenchymal stem cells-encapsulating hydrogel based on collagen for osteogenic differentiation. Colloids and Surfaces B: Biointerfaces 2019, 174, 528-535.
3. Zu, G.; Cao, Y.; Dong, J.; Zhou, Q.; van Rijn, P.; Liu, M.*; Pei, R.*, Development of an Aptamer-Conjugated Polyrotaxane-Based Biodegradable Magnetic Resonance Contrast Agent for Tumor-Targeted Imaging. ACS Applied Bio Materials 2019, DOI: 10.1021/acsabm.8b00639.
4. Zhang, Y.; Zhang, T.; Liu, M.*; Kuang, Y.; Zu, G.; Zhang, K.; Cao, Y.; Pei, R.*, Aptamer-Targeted Magnetic Resonance Imaging Contrast Agents and Their Applications. Journal of Nanoscience and Nanotechnology 2018, 18 (6), 3759-3774.
5. Zhang, Y.; Chen, H.; Zhang, T.; Zan, Y.; Ni, T.; Liu, M.*; Pei, R.*, Fast-forming BMSC-encapsulating hydrogels through bioorthogonal reaction for osteogenic differentiation. Biomaterials Science 2018, 6 (10), 2578-2581.
6. Chen, H.; Zhang, Y.; Ding, P.; Zhang, T.; Zan, Y.; Ni, T.; Lin, R.; Liu, M.*; Pei, R.*, Bone Marrow-Derived Mesenchymal Stem Cells Encapsulated in Functionalized Gellan Gum/Collagen Hydrogel for Effective Vascularization. ACS Applied Bio Materials 2018, 1 (5), 1408-1415.
7. Zu, G.; Tong, X.; Zhang, T.; Cao, Y.; Kuang, Y.; Zhang, K.; Zhang, Y.; Luo, L.; Liu, M.*; Pei, R.*, PEGylated chitosan grafted with polyamidoamine-dendron as tumor-targeted magnetic resonance imaging contrast agent. New Journal of Chemistry 2017, 41 (15), 7689-7696.
8. Zu, G.; Kuang, Y.; Dong, J.; Zhang, T.; Cao, Y.; Liu, M.*; Luo, L.; Pei, R.*, Gadolinium(III)-based Polymeric Magnetic Resonance Imaging Agents for Tumor Imaging. 2018, 25, 2910-2937.
9. Zu, G.; Kuang, Y.; Dong, J.; Cao, Y.; Wang, K.; Liu, M.*; Luo, L.; Pei, R.*, Multi-arm star-branched polymer as an efficient contrast agent for tumor-targeted magnetic resonance imaging. Journal of Materials Chemistry B 2017, 5 (25), 5001-5008.
10. Zhang, Y.; Wang, J.; Cheng, H.; Sun, N.; Liu, M.*; Wu, Z.; Pei, R.*, Inducible Bcl-2 gene RNA interference mediated by aptamer-integrated HDV ribozyme switch. Integrative Biology 2017, 9 (7), 619-626.
11. Zhang, K.; Cao, Y.; Kuang, Y.; Liu, M.*;Chen, Y.; Wang, Z.; Hong, S.; Wang, J.; Pei, R.*, Gd2O3 and GH combined with red blood cells to improve the sensitivity of contrast agents for cancer targeting MR imaging. Biomaterials Science 2017, 5 (1), 46-49.
12. Wang, H.; Wang, J.; Wang, Q.; Chen, X.; Liu, M.*;Chen, H.; Pei, R.*, Selection and characterization of dimethylindole red DNA aptamers for the development of light-up fluorescent probes. Talanta 2017, 168, 217-221.
13. Kuang, Y.; Zhang, K.; Cao, Y.; Chen, X.; Wang, K.; Liu, M.*; Pei, R.*, Hydrophobic IR-780 Dye Encapsulated in cRGD-Conjugated Solid Lipid Nanoparticles for NIR Imaging-Guided Photothermal Therapy. Acs Applied Materials & Interfaces 2017, 9 (14), 12217-12226.
14. Jiang, G.; Chen, X.; Xu, L.; Cao, Y.; Hong, S.; Liu, M.*; Cao, W.; Pei, R.*, Design and Synthesis of a Dimethylindole Red Trimer: A New Light-Up Red-Emitting Fluorescent Probe for G-Quadruplexes. Chemistryselect 2017, 2 (9), 2783-2788.
15. Cao, Y.; Liu, M.*; Zu, G.; Kuang, Y.; Tong, X.; Xiong, D.; Pei, R.*, Hyperbranched poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging in vivo. Polymer Chemistry 2017, 8 (6), 1104-1113.
16. Zhang, Y.; Wang, J.; Cheng, H.; Sun, Y.; Liu, M.*;Wu, Z.; Pei, R.*, Conditional control of suicide gene expression in tumor cells with theophylline-responsive ribozyme. Gene Therapy 2016, 24, 84.
17. Hong, S.; Sun, N.; Liu, M.*; Wang, J.; Pei, R.*, Building a chimera of aptamer-antisense oligonucleotide for silencing galectin-1 gene. RSC Advances 2016, 6 (113), 112445-112450.

共一或第一作者
18. Cao, Y.#; Liu, M.#;Zhang, K.; Zu, G.; Kuang, Y.; Tong, X.; Xiong, D.; Pei, R., Poly(glycerol) Used for Constructing Mixed Polymeric Micelles as T1 MRI Contrast Agent for Tumor-Targeted Imaging. Biomacromolecules 2017, 18 (1), 150-158.
19. Zu, G. #; Liu, M.#;Zhang, K.; Hong, S.; Dong, J.; Cao, Y.; Jiang, B.; Luo, L.; Pei, R., Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging. Biomacromolecules 2016, 17 (6), 2302-2308.
20. Tong, X. #; Liu, M.#;Zhang, K.; Cao, Y.; Dong, J.; Jiang, B.; Lu, B.; Zheng, H.; Zhang, H.; Pei, R., Oligoethylenimine-Grafted Chitosan as Enhanced T-1 Contrast Agent for In Vivo Targeted Tumor MRI. Journal of Magnetic Resonance Imaging 2016, 44 (1), 23-29.
21. Shen, H. #; Liu, M.#;Zhang, Z., Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy. Journal of Nanoscience and Nanotechnology 2016, 16 (3), 2210-2217.
22. Jiang, B. #; Liu, M.#; Zhang, K.; Zu, G.; Dong, J.; Cao, Y.; Zhang, L.; Pei, R., Oligoethylenimine grafted PEGylated poly(aspartic acid) as a macromolecular contrast agent: properties and in vivo studies. Journal of Materials Chemistry B 2016, 4 (19), 3324-3330.
23. Dong, J. #; Liu, M.#; Zhang, K.; Cao, Y.; Jiang, B.; Zu, G.; Pei, R., Biocleavable Oligolysine-Grafted Poly(disulfide amine)s as Magnetic Resonance Imaging Probes. Bioconjugate Chemistry 2016, 27 (1), 151-158.
24. Cao, Y. #; Liu, M.#;Zhang, K.; Dong, J.; Zu, G.; Chen, Y.; Zhang, T.; Xiong, D.; Pei, R., Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging. Journal of Materials Chemistry B 2016, 4 (41), 6716-6725.
25. Shen, H. #; Liu, M.#; Chong, Y.; Huang, J.; Zhang, Z., Synthesis, protein delivery, and in vitro and in vivo toxicity of a biodegradable poly(aminoester). Toxicology Research 2013, 2 (6), 379-387.
26. Shen, H. #; Liu, M.#; He, H.; Zhang, L.; Huang, J.; Chong, Y.; Dai, J.; Zhang, Z., PEGylated Graphene Oxide-Mediated Protein Delivery for Cell Function Regulation. Acs Applied Materials & Interfaces 2012, 4 (11), 6317-6323.
27. Liu, W.-M. #; Liu, M.#;Xue, Y.-N.; Peng, N.; Xia, X.-M.; Zhuo, R.-X.; Huang, S.-W., Poly(amidoamine)s with pendant primary amines and flexible backbone for enhanced nonviral gene delivery: Transfection and intracellular trafficking. Journal of Biomedical Materials Research Part A 2012, 100A (4), 872-881.
28. Liu, M.;Chen, B.; Xue, Y.; Huang, J.; Zhang, L.; Huang, S.; Li, Q.; Zhang, Z., Polyamidoamine-Grafted Multiwalled Carbon Nanotubes for Gene Delivery: Synthesis, Transfection and Intracellular Trafficking. Bioconjugate Chemistry 2011, 22 (11), 2237-2243.
29. Liu, M.;Chen, J.; Cheng, Y.-P.; Xue, Y.-N.; Zhuo, R.-X.; Huang, S.-W., Novel Poly(amidoamine)s with Pendant Primary Amines as Highly Efficient Gene Delivery Vectors. Macromolecular Bioscience 2010, 10 (4), 384-392.
30. Liu, M.; Chen, J.; Xue, Y.-N.; Liu, W.-M.; Zhuo, R.-X.; Huang, S.-W., Poly(beta-aminoester)s with Pendant Primary Amines for Efficient Gene Delivery. Bioconjugate Chemistry 2009, 20 (12), 2317-2323.

其它作者
31. Kuang, Y.; Cao, Y.; Liu, M.;Zu, G.; Zhang, Y.; Zhang, Y.; Pei, R., Geometrical confinement of gadolinium oxide nanoparticles in PEG/RGD-modified mesoporous carbon nanospheres as an enhanced T1 MRI contrast agent. ACS Applied Materials & Interfaces 2018.
32. Cao, Y.; Zu, G.; Kuang, Y.; He, Y.; Mao, Z.; Liu, M.;Xiong, D.; Pei, R., Biodegradable Nano-globular Magnetic Resonance Imaging Contrast Agent Constructed with Host-guest Self-assembly for Tumor-targeted Imaging. ACS Applied Materials & Interfaces 2018.
33. Wang, Z.; Sun, N.; Liu, M.; Cao, Y.; Wang, K.; Wang, J.; Pei, R., Multifunctional Nanofibers for Specific Purification and Release of CTCs. Acs Sensors 2017, 2 (4), 547-552.
34. Cao, Y.; Liu, M.; Kuang, Y.; Zu, G.; Xiong, D.; Pei, R., A poly(epsilon-caprolactone)-poly(glycerol)-poly(epsilon-caprolactone) triblock copolymer for designing a polymeric micelle as a tumor targeted magnetic resonance imaging contrast agent. Journal of Materials Chemistry B 2017, 5 (42), 8408-8416.
35. Xu, L.; Wang, J.; Sun, N.; Liu, M.;Cao, Y.; Wang, Z.; Pei, R., Neutral red as a specific light-up fluorescent probe for i-motif DNA. Chemical Communications 2016, 52 (99), 14330-14333.
36. Sun, N.; Liu, M.;Wang, J.; Wang, Z.; Li, X.; Jiang, B.; Pei, R., Chitosan Nanofibers for Specific Capture and Nondestructive Release of CTCs Assisted by pCBMA Brushes. Small 2016, 12 (36), 5090-5097.
37. Cheng, H.; Zhang, Y.; Wang, H.; Sun, N.; Liu, M.;Chen, H.; Pei, R., Regulation of MAP4K4 gene expression by RNA interference through an engineered theophylline-dependent hepatitis delta virus ribozyme switch. Molecular Biosystems 2016, 12 (11), 3370-3376.
38. Chen, X.; Wang, J.; Jiang, G.; Zu, G.; Liu, M.; Zhou, L.; Pei, R., The development of a light-up red-emitting fluorescent probe based on a G-quadruplex specific cyanine dye. Rsc Advances 2016, 6 (74), 70117-70123.
39. Zhang, K.; Liu, M.;Tong, X.; Sun, N.; Zhou, L.; Cao, Y.; Wang, J.; Zhang, H.; Pei, R., Aptamer-Modified Temperature-Sensitive Liposomal Contrast Agent for Magnetic Resonance Imaging. Biomacromolecules 2015, 16 (9), 2618-2623.
40. Wang, K.; Xu, L.; Sun, N.; Wang, Z.; Hong, S.; Wang, J.; Liu, M.;Pei, R., A novel photoelectrochemical aptasensor based on the modulation of a dye sensitized TiO2 photoelectrode. Analytical Methods 2015, 7 (18), 7443-7446.
41. Zhang, L.; Wang, Z.; Lu, Z.; Shen, H.; Huang, J.; Zhao, Q.; Liu, M.;He, N.; Zhang, Z., PEGylated reduced graphene oxide as a superior ssRNA delivery system. Journal of Materials Chemistry B 2013, 1 (6), 749-755.
42. Shen, H.; Zhang, L.; Liu, M.; Zhang, Z., Biomedical Applications of Graphene. Theranostics 2012, 2 (3), 283-294.
43. Huang, J.; Zong, C.; Shen, H.; Liu, M.;Chen, B.; Ren, B.; Zhang, Z., Mechanism of Cellular Uptake of Graphene Oxide Studied by Surface-Enhanced Raman Spectroscopy. Small 2012, 8 (16), 2577-2584.
44. Chen, W.; Cao, Y.; Liu, M.; Zhao, Q.; Huang, J.; Zhang, H.; Deng, Z.; Dai, J.; Williams, D. F.; Zhang, Z., Rotavirus capsid surface protein VP4-coated Fe3O4 nanoparticles as a theranostic platform for cellular imaging and drug delivery. Biomaterials 2012, 33 (31), 7895-7902.
45. Chen, B.; Liu, M.;Zhang, L.; Huang, J.; Yao, J.; Zhang, Z., Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. Journal of Materials Chemistry 2011, 21 (21), 7736-7741.
46. Zhang, M.; Xue, Y.-N.; Liu, M.;Zhuo, R.-X.; Huang, S.-W., Biocleavable Polycationic Micelles as Highly Efficient Gene Delivery Vectors. Nanoscale Research Letters 2010, 5 (11), 1804-1811.
47. Xue, Y.-N.; Liu, M.;Peng, L.; Huang, S.-W.; Zhuo, R.-X., Improving Gene Delivery Efficiency of Bioreducible Poly(amidoamine)s via Grafting with Dendritic Poly(amidoamine)s. Macromolecular Bioscience 2010, 10 (4), 404-414.
48. Zhang, M.; Liu, M.;Xue, Y.-N.; Huang, S.-W.; Zhuo, R.-X., Polyaspartamide-Based Oligo-ethylenimine Brushes with High Buffer Capacity and Low Cytotoxicity for Highly Efficient Gene Delivery. Bioconjugate Chemistry 2009, 20 (3), 440-446.
49. Xue, Y.-N.; Huang, Z.-Z.; Zhang, J.-T.; Liu, M.;Zhang, M.; Huang, S.-W.; Zhuo, R.-X., Synthesis and self-assembly of amphiphilic poly(acrylic acid-b-DL-lactide) to form micelles for pH-responsive drug delivery. Polymer 2009, 50 (15), 3706-3713.
50. Peng, L.; Liu, M.;Xue, Y.-N.; Huang, S.-W.; Zhuo, R.-X., Transfection and intracellular trafficking characteristics for poly(amidoamine)s with pendant primary amine in the delivery of plasmid DNA to bone marrow stromal cells. Biomaterials 2009, 30 (29), 5825-5833.
51. Chen, J.; Huang, S.-W.; Liu, M.;Zhuo, R.-X., Synthesis and degradation of poly(beta-aminoester) with pendant primary amine. Polymer 2007, 48 (3), 675-681.